Tanaka gave up a home run to Reyes on the first pitch of the game, then earned his major league-high 11th victory as the New York Yankees beat Toronto 3-1 Tuesday night for their 14th straight home win over the Blue Jays.
That was the first time Tanaka could remember getting tagged so quickly and said it "threw me off my rhythm a little bit."
"Overall, I think my stuff wasn't really there," he said through a translator.
Even so, Tanaka (11-1) struck out 10 in six innings and left with an AL-best 1.99 ERA. The right-hander has made 14 starts this season — he's gone at least six innings in every outing and never permitted more than three earned runs.
"What he's done is remarkable," Yankees manager Joe Girardi said. "He wins."
Brett Gardner hit a two-run homer off the right-field foul pole and the Yankees sent the AL East leaders to their seventh loss in 10 games.
Tanaka made his big league debut April 4 at Toronto and Melky Cabrera hit a leadoff home run on the third pitch.
Reyes provided an even faster start with a drive into the lower deck in right, and slapped his hands as he rounded first.
"I made up my mind before the game that I was going to swing at the first pitch," he said. "You don't want to face Tanaka with two strikes."
Said Girardi: "He just threw a pitch right down the middle and up. Reyes knew what to do."
"Reyes is familiar with this ballpark," he said. "He went to the short part of the park."
Cabrera followed with a liner between Tanaka's legs that knocked off the pitcher's glove. But Tanaka scrambled to retrieve the ball behind the mound and threw out Cabrera, and never again allowed a runner past second.
Tanaka gave up five hits and walked two in moving ahead of Toronto's Mark Buehrle for the most wins in the majors. Buehrle starts Wednesday night at Yankee Stadium in the middle game of the three-game series.
